Therefore, testing is required to identify the best treatment approach. Precision cancer treatments may be available for those with specific genetic mutations found via genomic testing. Our tests can also find less common cancer mutations, such as changes in the genes NTRK, ROS1, and ALK. These include changes in the genes EGFR, KRAS, BRAF, and PIK3CA. Our tumor genomic tests can find common genetic mutations linked to cancer. Molecular profiling also can help people with rare cancers, such as soft tissue sarcoma, thyroid cancer, and metastatic melanoma (skin cancer). Tumor molecular profiling can help people with common cancers, such as lung cancer, breast cancer, colorectal cancer, and prostate cancer. Tumor Genetic Testing Helps MSK Treat Common and Rare Cancer Types Tumor genetic testing can also provide your doctor with important information that can help decide whether other treatments, including surgery or radiation therapy, are indicated. Information about the likely outcome of your disease (your prognosis). Our patients have access to new treatments in development before they’re widely available. MSK has one of the largest cancer clinical trials programs in the country. Whether you’re a good match for one of our clinical trials, also known as research studies.Which drugs are not likely to work, so you can avoid treatments you don’t need, and their side effects. The best treatment choices based on the tumor’s genetic profile, as well as information from MSK’s unique database called OncoKB®. Tumor genomic tests that use next-generation DNA sequencing give us important details about the kind of cancer you have, such as:Ī more precise diagnosis of the type of tumor that you have. What Are the Benefits of Tumor Genetic Tests? It also helps doctors tell how well the cancer is responding to treatment. MSK-ACCESS® can do the same thing noninvasively by detecting tumor mutations in blood. MSK-IMPACT® looks for mutations in tumor cells that are linked to cancer in order to guide treatment.MSK offers two next-generation DNA sequencing tests for our patients. The blood sample test is called a liquid biopsy. The tumor sample from a prior surgery or biopsy can be used, or your doctor may request a new biopsy to collect a sample for genomic testing. What Is a Tumor Genetic Profiling Test?Ī tumor genetic profiling test is often called “genomic testing” or “molecular profiling.” The test uses a sample from your tumor, your blood, or both. Your Memorial Sloan Kettering Cancer Center (MSK) doctor may suggest these genetic tests, especially if cancer has spread to your lymph nodes or another body part. These DNA mutations may be inherited from your parents or acquired during your lifetime. Tumor genetic profiling tests show whether cancer is caused by certain genetic changes. If you have been diagnosed with cancer, it’s important to get information about the genetic changes (mutations or variants) in your tumor.
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